Khoom Taw Qhia
Phenylguanidine Hydrogen Carbonateyog ib tug siab -purity organic intermediate dav siv nyob rau hauv lub synthesis ntawm pharmaceuticals, agrochemicals, thiab tshwj xeeb tshuaj. Nws belongs rau guanidine derivative tsev neeg thiab ua hauj lwm raws li ib tug ntau yam precursor rau tsim nitrogen-muaj heterocycles xws li pyrimidines, triazines, thiab benzimidazoles.
Nrog rau kev ruaj ntseg zoo thiab kev ua haujlwm siab, qhov nruab nrab no ua rau muaj txiaj ntsig zoo sib txuas thiab kev sib tw cyclization nyob rau hauv cov xwm txheej me me, ua rau nws yog qhov kev xaiv zoo tshaj plaws rau ntau yam -kauj ruam organic synthesis.
Cov yam ntxwv tseem ceeb:
- High purity (Ntau dua lossis sib npaug li 99%) nrog cov khoom sib xws -rau -batch zoo
- Tsawg hygroscopicity, yooj yim los lis thiab khaws cia
- Soluble nyob rau hauv polar solvents (dej, cawv, DMF)
- Haum rau scale -nce ntawm R&D mus rau kev lag luam ntau lawm
Khoom Paub meej
|
Yam khoom |
Specification |
|
Lub Npe |
Phenylguanidine Hydrogen Carbonate |
|
Kev tsim qauv |
Crystalline hmoov |
|
Purity |
Ntau dua lossis sib npaug li 99% (HPLC) |
|
CAS Nr |
6685-76-3 |
|
Chemical Class |
Guanidine derivative |
|
Qhov tshwm sim |
Dawb rau tawm -dawb crystalline hmoov |
|
Molecular Formula |
C₈H₁₁N₃O₃ |
|
Melting Point |
150-154℃(lub kaum hli ntuj) |
|
Solubility |
Soluble hauv dej, ethanol, DMF |
|
Txee lub neej |
2 xyoos nyob rau hauv kaw, qhuav mob |
Hom Kev Ua Haujlwm (Chemical Properties & Mechanism)
Raws li ib tug organic intermediate, Phenylguanidine Hydrogen Carbonate ua raws li ib tugguanidylating tus neeg sawv cevthiabnitrogen pubnyob rau hauv heterocyclic nplhaib tsim. Nws koom nrog:
- Cyclocondensation cov tshuaj tiv thaivnrog -dicarbonyl compounds los ua pyrimidines
- Lub nplhaib kawNrog aldehydes los tsim benzimidazoles
- Nucleophilic hloov pauvrau kev qhia guanidine moiety rau hauv lub hom phiaj molecules
- Daim ntawv hydrogen carbonate ntsev ua kom muaj kev ruaj ntseg zoo dua thiab kev tuav tau yooj yim dua piv rau lub hauv paus dawb, tsis muaj kev cuam tshuam txog kev ua haujlwm.
Khoom nta & Cov txiaj ntsig
Qhov Zoo Tshaj Plaws
- High purity (Ntau dua lossis sib npaug li 99%)- txo cov byproduct tsim
- Solubility zoo heevnyob rau hauv dej thiab cov organic solvents
- ruaj khov nyob rau hauv ambient cia- tsis muaj qhov tshwj xeeb inert cua yuav tsum tau
- Ntau yam reactivity- haum rau ntau txoj hauv kev hluavtaws
- Scalable- los ntawm chav kuaj mus rau industrial ntau lawm
Pom zoo daim ntawv thov
- Pharmaceutical intermediate (antiviral, antihypertensive agents)
- Agrochemical synthesis (fungicides, tshuaj tua kab mob)
- Dye thiab pigment intermediates
- Organic semiconductor khoom
Cov cheeb tsam tseem ceeb ntawm daim ntawv thov
(1) Pharmaceutical Intermediates
Daim ntawv thov:Synthesis ntawm antihypertensive tshuaj (xws li, guanabenz analogs), tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob.
Cov txiaj ntsig tseem ceeb:
- Ua kom muaj txiaj ntsig zoo ntawm guanidine-muaj APIs
- Cov tshuaj tiv thaiv siab tawm los nyob rau hauv cov mob me
- Kev purity tsis tu ncua ua kom muaj kev tswj hwm kev ua raws cai
(2) Agrochemical Synthesis
Daim ntawv thov:Lub tsev thaiv rau fungicides (piv txwv li, cyprodinil analogs) thiab cog kev loj hlob regulators.
Cov txiaj ntsig tseem ceeb:
- Muab guanidine qaum rau cov tshuaj tua kab heterocyclic
- Txo cov kauj ruam hluavtaws piv rau lwm txoj hauv kev
- Tus nqi -zoo rau kev lag luam nplai
(3) Heterocyclic Fine Chemicals
Daim ntawv thov:Kev tsim cov pyrimidines, triazines, thiab benzimidazoles rau dyes, UV absorbers, thiab cov ntaub ntawv tshwj xeeb.
Cov txiaj ntsig tseem ceeb:
- High regioselectivity nyob rau hauv cyclization tshwm sim
- Ntxuav cov khoom siv hluav taws xob (CO₂ thiab dej)
- Haum rau cov txheej txheem ntsuab chemistry
(4) Kev Tshawb Fawb & Kev Txhim Kho
Daim ntawv thov:Qhov tseem ceeb reagent rau tshuaj chemistry, combinatorial chemistry, thiab kev tshawb fawb kev kawm.
Cov txiaj ntsig tseem ceeb:
- Yooj yim muaj nyob rau hauv me me
- ruaj khov thaum lub sij hawm ntev - khaws cia
- Muaj kev txhawb nqa dav
Ntim & Khoom
- 100g / 500g / 1 kg / 25 kg
- Kev ntim khoom muaj (PE hnab, aluminium ntawv ci hnab)
- OEM & ntiag tug daim ntawv lo txhawb nqa rau downstream derivatives
Quality Assurance
Manufactured nyob rau hauv nruj zoo tswj system
Txhawb nqa los ntawm:
- Tag nrho cov ntaub ntawv tsom xam pob
- Batch-rau-batch sib xws
- Daim ntawv ruaj khov crystalline nrog lub neej txee zoo heev
Cov lus nug nquag nug (FAQ)
A. Phenylguanidine Hydrogen Carbonate tsuas yog siv rau dab tsi?
Nws yog ntau yam nruab nrab rau kev sib xyaw tshuaj (xws li, tshuaj tiv thaiv kab mob), agrochemicals (fungicides), thiab heterocyclic nplua tshuaj.
B. Nws txawv li cas ntawm phenylguanidine dawb puag?
Lub hydrogen carbonate ntsev muaj kev ruaj ntseg zoo dua thermal stability, qis hygroscopicity, thiab yooj yim tuav dua li lub hauv paus dawb, thaum tswj kev sib piv reactivity nyob rau hauv feem ntau txoj kev hluavtaws.
C. Cov xwm txheej tshwm sim li cas?
Nws reacts nrog -dicarbonyl compounds, aldehydes, los yog isothiocyanates nyob rau hauv polar solvents (ethanol, dej, DMF) ntawm 60-120℃. Cov hydrogen carbonate tuaj yeem decompose kom tso CO₂, uas tuaj yeem ua tau zoo hauv qee qhov kev sib tw.
D. Cov khoom no puas haum rau GMP kev tsim tshuaj?
Yog lawm. Peb muab tag nrho cov ntaub ntawv suav nrog DMF (Drug Master File) kev txhawb nqa, impurity profiles, thiab cov ntaub ntawv ruaj khov thaum thov.
E. Yuav tsum khaws thiab tuav li cas?
Khaws rau hauv qhov chaw txias, qhuav hauv cov thawv kaw nruj nreem. Tsis txhob raug cov av noo ntev ntev. Nws tsis yog - txaus ntshai nyob rau hauv ib txwm tuav, tab sis tus qauv kuaj kev nyab xeeb yuav tsum tau ua raws.
F. Koj puas tuaj yeem muab kev cai particle loj lossis qib recrystallized?
Yog lawm. Peb muab kev pabcuam milling, micronization, thiab recrystallization kom tau raws li cov txheej txheem hauv qab no.
G. Lub neej txee lub neej yog dab tsi?
2 xyoo thaum khaws cia rau hauv cov khoom ntim tsis tau qhib raws li kev pom zoo.
H. Koj puas txhawb nqa cov qauv thov rau R & D?
Yog lawm. Cov qauv dawb (txog 100 g) muaj rau cov tuam txhab tsim nyog thiab cov tuam txhab. Cov nqi xa khoom tuaj yeem siv tau.
Cim npe nrov: Tuam Tshoj phenylguanidine hydrogen carbonate manufacturers, lwm tus neeg, Hoobkas

